The activation of the alternative pathway C3 convertase by human plasma kallikrein.

@article{Discipio1982TheAO,
  title={The activation of the alternative pathway C3 convertase by human plasma kallikrein.},
  author={Richard G. Discipio},
  journal={Immunology},
  year={1982},
  volume={45 3},
  pages={587-95}
}
Human plasma kallikrein can replace factor D for the activation of the alternative pathway C3 convertase of human complement. The factor B cleavage patterns by factor D and kallikrein are indistinguishable. The ability of kallikrein to cleave factor B is influenced by the magnesium ion concentration and the C3b concentration. Factor D is about ten-fold more effective on a molar basis, for the alternative pathway C3 convertase activation than is kallikrein. The physiological role of the action… CONTINUE READING

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