The activation of the WNT signaling pathway is a Hallmark in neurofibromatosis type 1 tumorigenesis.

Abstract

PURPOSE The hallmark of neurofibromatosis type 1 (NF1) is the onset of dermal or plexiform neurofibromas, mainly composed of Schwann cells. Plexiform neurofibromas can transform into malignant peripheral nerve sheath tumors (MPNST) that are resistant to therapies. EXPERIMENTAL DESIGN The aim of this study was to identify an additional pathway in the NF1… (More)
DOI: 10.1158/1078-0432.CCR-13-0780