The activation of protein degradation in muscle by Ca2+ or muscle injury does not involve a lysosomal mechanism.

@article{Furuno1986TheAO,
  title={The activation of protein degradation in muscle by Ca2+ or muscle injury does not involve a lysosomal mechanism.},
  author={Katsushi Furuno and Alfred L Goldberg},
  journal={The Biochemical journal},
  year={1986},
  volume={237 3},
  pages={859-64}
}
By use of different inhibitors, we distinguished three proteolytic processes in rat skeletal muscle. When soleus muscles maintained under tension were exposed to the calcium ionophore A23187 or were incubated under no tension in the presence of Ca2+, net protein breakdown increased by 50-80%. Although leupeptin and E-64 inhibit this acceleration of protein breakdown almost completely, other agents that prevent lysosomal function, such as methylamine or leucine methyl ester, did not inhibit this… CONTINUE READING
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