The activation of inactive membrane-associated protein kinase C is associated with DMSO-induced erythroleukemia cell differentiation.

@article{Chakravarthy1992TheAO,
  title={The activation of inactive membrane-associated protein kinase C is associated with DMSO-induced erythroleukemia cell differentiation.},
  author={Balu R Chakravarthy and Roger G Tremblay and Paula Macdonald and Velibor Krsmanovi{\'c} and James F. Whitfield and Jon P. Durkin},
  journal={Biochimica et biophysica acta},
  year={1992},
  volume={1136 1},
  pages={83-90}
}
The rapid redistribution of cytosolic protein kinase C (PKC) to membranes and its subsequent proteolytic activation to PKM have been implicated in the DMSO/HMBA-induced differentiation of murine erythroleukemia (MEL) cells. However, DMSO was found not to induce detectable changes in PKC distribution in a MEL cell subline (MEL1) which differentiated normally in response to the agent. Nevertheless, the differentiation of MEL1 cells appeared dependent on an early PKC-related event because… CONTINUE READING