The activation of factor VII in citrated plasma by charged long-chain saturated fatty acids at the interface of large triglyceride-rich lipoproteins.

@article{Mitropoulos1993TheAO,
  title={The activation of factor VII in citrated plasma by charged long-chain saturated fatty acids at the interface of large triglyceride-rich lipoproteins.},
  author={Kostas A. Mitropoulos and B E Reeves and George J. Miller},
  journal={Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis},
  year={1993},
  volume={4 6},
  pages={943-51}
}
The prolonged incubation of dilute plasma on ice in the presence of added sulphatide vesicles or the long-chain saturated fatty acids (FA) stearic acid (C18:0) or behenic acid (C22:0) induced a concentration-dependent increase in factor VII coagulant activity (VIIc). The addition of FA at various ratios to human serum albumin showed the micellar non-bound pool to be responsible for this effect, FA bound to the high-affinity or low-affinity binding sites of albumin having no influence on VIIc… CONTINUE READING