The activation of electrophile, nucleophile and leaving group during the reaction catalysed by pI258 arsenate reductase.

@article{Roos2006TheAO,
  title={The activation of electrophile, nucleophile and leaving group during the reaction catalysed by pI258 arsenate reductase.},
  author={Goedele Roos and Stefan Loverix and Elke Brosens and Kunegunda Belle and Lode Wyns and Paul Geerlings and Joris Messens},
  journal={Chembiochem : a European journal of chemical biology},
  year={2006},
  volume={7 6},
  pages={
          981-9
        }
}
The reduction of arsenate to arsenite by pI258 arsenate reductase (ArsC) combines a nucleophilic displacement reaction with a unique intramolecular disulfide cascade. Within this reaction mechanism, the oxidative equivalents are translocated from the active site to the surface of ArsC. The first reaction step in the reduction of arsenate by pI258 ArsC consists of a nucleophilic displacement reaction carried out by Cys10 on dianionic arsenate. The second step involves the nucleophilic attack of… CONTINUE READING
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