The activation of Wnt signaling by a STAT6-dependent macrophage phenotype promotes mucosal repair in murine IBD

@article{CosinRoger2016TheAO,
  title={The activation of Wnt signaling by a STAT6-dependent macrophage phenotype promotes mucosal repair in murine IBD},
  author={Jesus Cosin-Roger and Dolores Ortiz-Masi{\'a} and Sara Calatayud and Carlos Hern{\'a}ndez and Juan V Esplugues and Mar{\'i}a D Barrachina},
  journal={Mucosal Immunology},
  year={2016},
  volume={9},
  pages={986-998}
}
The complete repair of the mucosa constitutes a key goal in inflammatory bowel disease (IBD) treatment. The Wnt signaling pathway mediates mucosal repair and M2 macrophages that coordinate efficient healing have been related to Wnt ligand expression. Signal transducer and activator of transcription 6 (STAT6) mediates M2 polarization in vitro and we hypothesize that a STAT6-dependent macrophage phenotype mediates mucosal repair in acute murine colitis by activating the Wnt signaling pathway. Our… CONTINUE READING
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