The activation of 5‐HT2A receptors in prefrontal cortex enhances dopaminergic activity
@article{Bortolozzi2005TheAO, title={The activation of 5‐HT2A receptors in prefrontal cortex enhances dopaminergic activity}, author={Anal{\'i}a Bortolozzi and Llorenç D{\'i}az-Mataix and Mar{\'i}a Cecilia Scorza and Pau Celada and Francesc Casa{\~n}as Artigas}, journal={Journal of Neurochemistry}, year={2005}, volume={95} }
Atypical antipsychotics show preferential 5‐HT2A versus dopamine (DA) D2 receptor affinity. At clinical doses, they fully occupy cortical 5‐HT2 receptors, which suggests a strong relationship with their therapeutic action. Half of the pyramidal neurones in the medial prefrontal cortex (mPFC) express 5‐HT2A receptors. Also, neurones excited through 5‐HT2A receptors project to the ventral tegmental area (VTA). We therefore hypothesized that prefrontal 5‐HT2A receptors can modulate DA transmission…
182 Citations
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The results suggest that the activation of mPFC 5-HT1A receptors enhances the activity of VTA DA neurons and mesocortical DA release, which may be involved in the elevation of extracellular DA produced by atypical antipsychotics.
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The absence of 5-HT1A receptors has minor effects on dopamine but not serotonin release evoked by MK-801 in mice prefrontal cortex
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- 2008
The lack of effect observed after the local MK-801 application suggests that the change in cortical monoamines is mainly driven by subcortical NMDA receptor blockade, without a significant involvement of PFC 5-HT1A receptors.
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