The activation of 5‐HT2A receptors in prefrontal cortex enhances dopaminergic activity

@article{Bortolozzi2005TheAO,
  title={The activation of 5‐HT2A receptors in prefrontal cortex enhances dopaminergic activity},
  author={A. Bortolozzi and L. D{\'i}az-Mataix and M. Scorza and P. Celada and F. Artigas},
  journal={Journal of Neurochemistry},
  year={2005},
  volume={95}
}
  • A. Bortolozzi, L. Díaz-Mataix, +2 authors F. Artigas
  • Published 2005
  • Psychology, Medicine
  • Journal of Neurochemistry
    • Atypical antipsychotics show preferential 5‐HT2A versus dopamine (DA) D2 receptor affinity. At clinical doses, they fully occupy cortical 5‐HT2 receptors, which suggests a strong relationship with their therapeutic action. Half of the pyramidal neurones in the medial prefrontal cortex (mPFC) express 5‐HT2A receptors. Also, neurones excited through 5‐HT2A receptors project to the ventral tegmental area (VTA). We therefore hypothesized that prefrontal 5‐HT2A receptors can modulate DA transmission… CONTINUE READING
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    References

    SHOWING 1-10 OF 89 REFERENCES
    5‐HT2A and D2 receptor blockade increases cortical DA release via 5‐HT1A receptor activation: a possible mechanism of atypical antipsychotic‐induced cortical dopamine release
    • 500
    Serotonin2C receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: A combined dialysis and electrophysiological analysis in the rat
    • 318
    M100,907, a selective 5-HT2A antagonist, attenuates dopamine release in the rat medial prefrontal cortex
    • 119
    Co-expression and in vivo interaction of serotonin1A and serotonin2A receptors in pyramidal neurons of prefrontal cortex.
    • 312
    • PDF
    M 100 , 907 , a selective 5-HT antagonist , attenuates dopamine release 2 A in the rat medial prefrontal cortex
    • 8
    • PDF
    Control of Serotonergic Function in Medial Prefrontal Cortex by Serotonin-2A Receptors through a Glutamate-Dependent Mechanism
    • 285
    • PDF
    Constitutive Activity of the Serotonin2C Receptor Inhibits In Vivo Dopamine Release in the Rat Striatum and Nucleus Accumbens
    • 303
    • PDF
    Localization of 5-HT2A receptors on dopamine cells in subnuclei of the midbrain A10 cell group
    • 154
    Role of 5-HT(2C) receptors in the control of central dopamine function.
    • 224
    In vivo modulation of the activity of pyramidal neurons in the rat medial prefrontal cortex by 5-HT2A receptors: relationship to thalamocortical afferents.
    • 185
    • PDF