The activation of 5‐HT2A receptors in prefrontal cortex enhances dopaminergic activity
@article{Bortolozzi2005TheAO, title={The activation of 5‐HT2A receptors in prefrontal cortex enhances dopaminergic activity}, author={A. Bortolozzi and L. D{\'i}az-Mataix and M. Scorza and P. Celada and F. Artigas}, journal={Journal of Neurochemistry}, year={2005}, volume={95} }
Atypical antipsychotics show preferential 5‐HT2A versus dopamine (DA) D2 receptor affinity. At clinical doses, they fully occupy cortical 5‐HT2 receptors, which suggests a strong relationship with their therapeutic action. Half of the pyramidal neurones in the medial prefrontal cortex (mPFC) express 5‐HT2A receptors. Also, neurones excited through 5‐HT2A receptors project to the ventral tegmental area (VTA). We therefore hypothesized that prefrontal 5‐HT2A receptors can modulate DA transmission… CONTINUE READING
Topics from this paper
168 Citations
Involvement of 5-HT1A Receptors in Prefrontal Cortex in the Modulation of Dopaminergic Activity: Role in Atypical Antipsychotic Action
- Medicine, Biology
- The Journal of Neuroscience
- 2005
- 252
- PDF
Involvement of 5‐HT2A receptor and α2‐adrenoceptor blockade in the asenapine‐induced elevation of prefrontal cortical monoamine outflow
- Chemistry, Medicine
- Synapse
- 2012
- 30
Expression of 5-HT2A receptors in prefrontal cortex pyramidal neurons projecting to nucleus accumbens. Potential relevance for atypical antipsychotic action
- Chemistry, Medicine
- Neuropharmacology
- 2014
- 30
- PDF
Stimulation of glutamate receptors in the ventral tegmental area is necessary for serotonin-2 receptor-induced increases in mesocortical dopamine release
- Chemistry, Medicine
- Neuroscience
- 2015
- 9
The absence of 5-HT1A receptors has minor effects on dopamine but not serotonin release evoked by MK-801 in mice prefrontal cortex
- Chemistry, Medicine
- Psychopharmacology
- 2008
- 14
- PDF
Dopamine release induced by atypical antipsychotics in prefrontal cortex requires 5-HT(1A) receptors but not 5-HT(2A) receptors.
- Chemistry, Medicine
- The international journal of neuropsychopharmacology
- 2010
- 74
- PDF
Dopamine and serotonin interactions in the prefrontal cortex: insights on antipsychotic drugs and their mechanism of action.
- Medicine
- Pharmacopsychiatry
- 2007
- 65
The serotonin 5-HT2C receptor and the non-addictive nature of classic hallucinogens
- Psychology, Medicine
- Journal of psychopharmacology
- 2017
- 22
- PDF
5-HT2 receptors modulate the expression of antipsychotic-induced dopamine supersensitivity
- Chemistry, Medicine
- European Neuropsychopharmacology
- 2015
- 18
- Highly Influenced
- PDF
References
SHOWING 1-10 OF 89 REFERENCES
5‐HT2A and D2 receptor blockade increases cortical DA release via 5‐HT1A receptor activation: a possible mechanism of atypical antipsychotic‐induced cortical dopamine release
- Chemistry, Medicine
- Journal of neurochemistry
- 2001
- 500
Serotonin2C receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: A combined dialysis and electrophysiological analysis in the rat
- Psychology, Medicine
- Synapse
- 2000
- 318
M100,907, a selective 5-HT2A antagonist, attenuates dopamine release in the rat medial prefrontal cortex
- Chemistry, Medicine
- Brain Research
- 2001
- 119
Co-expression and in vivo interaction of serotonin1A and serotonin2A receptors in pyramidal neurons of prefrontal cortex.
- Chemistry, Medicine
- Cerebral cortex
- 2004
- 312
- PDF
Control of Serotonergic Function in Medial Prefrontal Cortex by Serotonin-2A Receptors through a Glutamate-Dependent Mechanism
- Chemistry, Medicine
- The Journal of Neuroscience
- 2001
- 285
- PDF
Constitutive Activity of the Serotonin2C Receptor Inhibits In Vivo Dopamine Release in the Rat Striatum and Nucleus Accumbens
- Biology, Medicine
- The Journal of Neuroscience
- 2004
- 303
- PDF
Localization of 5-HT2A receptors on dopamine cells in subnuclei of the midbrain A10 cell group
- Biology, Medicine
- Neuroscience
- 2002
- 154
Role of 5-HT(2C) receptors in the control of central dopamine function.
- Medicine
- Trends in pharmacological sciences
- 2001
- 224
In vivo modulation of the activity of pyramidal neurons in the rat medial prefrontal cortex by 5-HT2A receptors: relationship to thalamocortical afferents.
- Medicine, Chemistry
- Cerebral cortex
- 2003
- 185
- PDF