The activation of 5‐HT2A receptors in prefrontal cortex enhances dopaminergic activity

@article{Bortolozzi2005TheAO,
  title={The activation of 5‐HT2A receptors in prefrontal cortex enhances dopaminergic activity},
  author={Anal{\'i}a Bortolozzi and Llorenç D{\'i}az-Mataix and Mar{\'i}a Cecilia Scorza and Pau Celada and Francesc Casa{\~n}as Artigas},
  journal={Journal of Neurochemistry},
  year={2005},
  volume={95}
}
Atypical antipsychotics show preferential 5‐HT2A versus dopamine (DA) D2 receptor affinity. At clinical doses, they fully occupy cortical 5‐HT2 receptors, which suggests a strong relationship with their therapeutic action. Half of the pyramidal neurones in the medial prefrontal cortex (mPFC) express 5‐HT2A receptors. Also, neurones excited through 5‐HT2A receptors project to the ventral tegmental area (VTA). We therefore hypothesized that prefrontal 5‐HT2A receptors can modulate DA transmission… 
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