The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB.

@article{Hagemeier1993TheAD,
  title={The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB.},
  author={Christian Hagemeier and Andrew J. Bannister and Atlanta Cook and Tony Kouzarides},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 4},
  pages={1580-4}
}
The retinoblastoma (RB) tumor suppressor protein and the TATA-box-binding protein TFIID form contacts with a number of viral transactivator proteins. One of these, the adenovirus E1A protein, can bind to both proteins. Here we present evidence that the cellular transcription factor PU.1 can bind to both RB and TFIID. Like E1A, PU.1 binds to the conserved C… CONTINUE READING