The activating dual phosphorylation of MAPK by MEK is nonprocessive.

  title={The activating dual phosphorylation of MAPK by MEK is nonprocessive.},
  author={W R Burack and Thomas W. Sturgill},
  volume={36 20},
Activation of mitogen-activated protein kinases (MAPKs), also known as extracellular-signal-regulated kinases (ERKs), by MAPK/extracellular protein kinase kinases (MEKs) requires phosphorylation at two sites. The first step in MAPK activation by MEK must be the formation of a MEK x MAPK enzyme-substrate complex, followed by phosphorylation producing monophosphorylated MAPK (pMAPK). Subsequently, one of two events may occur. (1) MEK catalyzes the second and fully activating phosphorylation of… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
73 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 73 extracted citations

Similar Papers

Loading similar papers…