The activating dual phosphorylation of MAPK by MEK is nonprocessive.

@article{Burack1997TheAD,
  title={The activating dual phosphorylation of MAPK by MEK is nonprocessive.},
  author={W R Burack and Thomas W. Sturgill},
  journal={Biochemistry},
  year={1997},
  volume={36 20},
  pages={5929-33}
}
Activation of mitogen-activated protein kinases (MAPKs), also known as extracellular-signal-regulated kinases (ERKs), by MAPK/extracellular protein kinase kinases (MEKs) requires phosphorylation at two sites. The first step in MAPK activation by MEK must be the formation of a MEK x MAPK enzyme-substrate complex, followed by phosphorylation producing monophosphorylated MAPK (pMAPK). Subsequently, one of two events may occur. (1) MEK catalyzes the second and fully activating phosphorylation of… CONTINUE READING

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