The actions of substance P and serotonin on myenteric neurons in tissue culture.

@article{Hanani1985TheAO,
  title={The actions of substance P and serotonin on myenteric neurons in tissue culture.},
  author={Menachem Hanani and Geoffrey Burnstock},
  journal={Brain research},
  year={1985},
  volume={358 1-2},
  pages={276-81}
}
Intracellular recordings were made from guinea-pig myenteric neurons in tissue culture. The responses to substance P (SP) and serotonin were compared. Putative transmitters were ejected by pressure from micropipettes. The response to SP was, in the majority of cases, a prolonged depolarization, with a latency of 1-5 s and a duration of 1-2 min. During the depolarization there was an increase in the input resistance of the cells, and the excitability was augmented. In two neurons the response to… CONTINUE READING

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