The actions of nitric oxide donors in the prevention or induction of injury to the rat gastric mucosa.

@article{LpezBelmonte1993TheAO,
  title={The actions of nitric oxide donors in the prevention or induction of injury to the rat gastric mucosa.},
  author={Jes{\'u}s L{\'o}pez-Belmonte and Brendan J. R. Whittle and Salvador Moncada},
  journal={British journal of pharmacology},
  year={1993},
  volume={108 1},
  pages={73-8}
}
1. The protective or damaging actions on the gastric mucosa, of locally infused nitrovasodilators that donate nitric oxide (NO), have been investigated in the pentobarbitone-anaesthetized rat. 2. Local intra-arterial infusion of endothelin-1 (ET-1; 5 pmol kg-1 min-1 for 10 min) induced extensive, macroscopically apparent, haemorrhagic injury to the rat gastric mucosa. This damage was dose-dependently reduced by concurrent local intra-arterial infusion of glyceryl trinitrate (GTN; 10-40… CONTINUE READING

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