The actions of bradykinin and eledoisin in the canine isolated kidney: relationships to prostaglandins.

@article{Mcgiff1975TheAO,
  title={The actions of bradykinin and eledoisin in the canine isolated kidney: relationships to prostaglandins.},
  author={J C Mcgiff and H D Itskovitz and N. A. Terragno},
  journal={Clinical science and molecular medicine},
  year={1975},
  volume={49 2},
  pages={
          125-31
        }
}
1. The effects of two vasodilator polypeptides, bradykinin and eledoisin, were studied in isolated blood-perfused canine kidneys before and after administration of indomethacin, an inhibitor of prostaglandin synthesis, Bradykinin, but not eledoisin, releases renal prostaglandins. 2. Before administration of indomethacin, bradykinin decreased urinary osmolality and increased free qater clearance, whereas eledoisin did not affect the excretion of solute-free water. After administration of… CONTINUE READING

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