The actions of 3,4-diaminopyridine in bullfrog sympathetic ganglia

@article{Apatoff1982TheAO,
  title={The actions of 3,4-diaminopyridine in bullfrog sympathetic ganglia},
  author={B. Apatoff and W. Riker},
  journal={Brain Research},
  year={1982},
  volume={252},
  pages={277-286}
}
The effects of 3,4-diaminopyridine (3,4-DAP) on isolated sympathetic ganglia were studied by means of intracellular and extracellular recording techniques. 3,4-DAP in micromolar concentrations caused a single orthodromic stimulus to generate a brief burst of repetitive postganglionic discharges. Such stimulus-bound repetition (SBR) appeared to represent a presynaptic action of 3,4-DAP, as no repetitive firing could be evoked by antidromic or direct stimulation of ganglion cells. 3,4-DAP also… Expand
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