The action of thrombin in intracerebral hemorrhage induced brain damage is mediated via PKCα/PKCδ signaling.

@article{Cui2011TheAO,
  title={The action of thrombin in intracerebral hemorrhage induced brain damage is mediated via PKCα/PKCδ signaling.},
  author={Gui-Yun Cui and Xiu-Ming Gao and S H Qi and Aleena Gillani and Li Gao and Xia Shen and Ying-Dong Zhang},
  journal={Brain research},
  year={2011},
  volume={1398},
  pages={86-93}
}
The present study investigates the role of protein kinase C alpha/delta (PKCα/PKCδ) in brain injury induced by intracerebral hemorrhage (ICH) by utilizing a rat model that received intracerebral injections of autologous blood and thrombin (TM). The activation and expression of PKC and PKCδ were analyzed by Western blot and immunohistochemistry. A PKC inhibitor, dihydrochloride (H7), was administrated intraperitoneally after injury to evaluate the effect of inhibition of PKC on ICH and TM… CONTINUE READING