The action of soluble and immobilized carboxylic proteinases on serum proteins

@article{Stepanov2004TheAO,
  title={The action of soluble and immobilized carboxylic proteinases on serum proteins},
  author={V. M. Stepanov and M. A. Tel'nova and Tatyana Kotova and V. P. Tel'bukh},
  journal={Chemistry of Natural Compounds},
  year={2004},
  volume={14},
  pages={655-660}
}
1. It has been shown that the carboxylic proteinases of microscopic fungi perform the limited proteolysis of immunoglobulin molecules. 2. Like porcine pepsin, aspergillopepsins A and F specifically cleave immunoglobulin molecules to F(ab′)2 and Fc fragments, the ratio of which was determined accurately by chromatography on Ultrogel AcA-44. More effective hydrolysis of immunoglobulin molecules in acid solutions by these enzymes than by porcine pepsin was observed. 3. Immobilized carboxylic… CONTINUE READING

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