The action of sevoflurane on vascular smooth muscle of isolated mesenteric resistance arteries (part 1): role of endothelium.

@article{Izumi2000TheAO,
  title={The action of sevoflurane on vascular smooth muscle of isolated mesenteric resistance arteries (part 1): role of endothelium.},
  author={Kiyoko Izumi and Takasi Akata and Shosuke Takahashi},
  journal={Anesthesiology},
  year={2000},
  volume={92 5},
  pages={1426-40}
}
BACKGROUND The direct action of sevoflurane on systemic resistance arteries is not fully understood. METHODS Isometric force was recorded in isolated rat small mesenteric arteries. RESULTS Sevoflurane (2-5%) enhanced contractile response to norepinephrine only in the presence of endothelium, but inhibited it in its absence. Sevoflurane still enhanced the norepinephrine response after inhibitions of the nitric oxide, endothelium-derived hyperpolarizing factor, cyclooxygenase and lipoxygenase… CONTINUE READING

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