The action of prostaglandin E2 on the human cervix: stimulation of interleukin 8 and inhibition of secretory leukocyte protease inhibitor.

@article{Denison1999TheAO,
  title={The action of prostaglandin E2 on the human cervix: stimulation of interleukin 8 and inhibition of secretory leukocyte protease inhibitor.},
  author={Fiona C Denison and Andrew A. Calder and Rodney W. Kelly},
  journal={American journal of obstetrics and gynecology},
  year={1999},
  volume={180 3 Pt 1},
  pages={614-20}
}
OBJECTIVE The objective of this study was to investigate regulation of inflammatory mediators implicated in cervical ripening and to explore the mechanisms by which the clinically effective agent prostaglandin E2 may mediate cervical ripening. STUDY DESIGN Cervical biopsy specimens were taken from healthy, nonpregnant women undergoing a hysterectomy for a benign nonmalignant condition and were cultured, with treatments in quadruplicate, for 24 hours in media supplemented with progesterone… CONTINUE READING
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