The action of human C3 in soluble or cross-linked form with resting and activated murine B lymphocytes.

@article{Erdei1985TheAO,
  title={The action of human C3 in soluble or cross-linked form with resting and activated murine B lymphocytes.},
  author={Anna Erdei and Fritz Georg Melchers and Thomas Schulz and Manfred Paul Dierich},
  journal={European journal of immunology},
  year={1985},
  volume={15 2},
  pages={184-8}
}
The third component of complement C3 has been implied in the stimulation of B lymphocytes to proliferation and maturation for Ig secretion. We have reinvestigated the extent of this activation with either activated or resting murine splenic lymphocytes in serum-substituted cultures. Human C3 was used in either soluble or cross-linked form. Soluble as well as Sepharose-bound or glutaraldehyde-cross-linked C3, over a range of concentrations, was inactive with resting splenic lymphocytes of (C57BL… CONTINUE READING