The action of erythropoietin is mediated by lipoxygenase metabolites in murine fetal liver cells.

@article{Beckman1987TheAO,
  title={The action of erythropoietin is mediated by lipoxygenase metabolites in murine fetal liver cells.},
  author={Barbara S. Beckman and MEREDITH MASON-GARCIA and L Nystuen and Lynn King and James W. Fisher},
  journal={Biochemical and biophysical research communications},
  year={1987},
  volume={147 1},
  pages={392-8}
}
Erythroid progenitor cells synthesize 12-hydroxyeicosatetraenoic acid (12-HETE) and 15-hydroxyeicosatetraenoic acid (15-HETE) when stimulated by erythropoietin (Ep). Maximal stimulation of 12-HETE production occurred at one hour, whereas 15-HETE activity remained constant in response to Ep for 24 hours. Lipoxygenase-selective inhibitors of arachidonic acid… CONTINUE READING