The action of dazopride to enhance gastric emptying and block emesis

@article{Costall1987TheAO,
  title={The action of dazopride to enhance gastric emptying and block emesis},
  author={Brenda Costall and Annette M. Domeney and Simon Joseph Gunning and M. Elizabeth Kelly and David Tattersall},
  journal={Neuropharmacology},
  year={1987},
  volume={26},
  pages={669-677}
}
The substituted benzamide derivatives, dazopride and metoclopramide, enhanced field stimulation-induced contractions of guinea-pig stomach strips and gastric emptying in the guinea-pig after peripheral, intracerebroventricular and intrahypothalamic injection. In the isolated vagal nerve preparation from the rabbit, both compounds were shown to be 5-hydroxytryptamine M-receptor antagonists. Dazopride and metoclopramide were equipotent in antagonising cisplatin-induced emesis in the ferret… Expand
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