The action of dazopride to enhance gastric emptying and block emesis

  title={The action of dazopride to enhance gastric emptying and block emesis},
  author={Brenda Costall and Annette M. Domeney and Simon Joseph Gunning and M. Elizabeth Kelly and Robert J. Naylor and Virinder Nohria and J. B. Owera-Atepo and K. M. Simpson and Connie C. W. Tan and David Tattersall},

Dose-ranging evaluation of the substituted benzamide dazopride when used as an antiemetic in patients receiving anticancer chemotherapy

Dazopride, a substituted benzamide structurally related to metoclopramide, is a potent gastric prokinetic agent that prevents cisplatin-induced emesis in animals and can be safely given at doses of up to 4.0 mg/kg to patients receiving chemotherapy.

The anti‐emetic effects of CP‐99,994 in the ferret and the dog: role of the NK1 receptor

The hypothesis that the NK1 receptor antagonist properties of CP‐99,994 are responsible for its broad spectrum anti‐emetic effects is supported and it is suggested that CP‐ 99,994 acts within the brainstem, most probably within the nucleus tractus solitarius although the involvement of the area postrema could not be excluded.

Role of D-1 and D-2 receptor stimulation in sensitization to amphetamine-induced circling behavior and in expression and extinction of the Pavlovian conditioned response

Circling behavior was measured in female rats treated with amphetamine (1.25 mg/kgd-amphetamine sulfate, IP) on 3 consecutive days. On days 4 and 5 saline was substituted for amphetamine. While the

The effect of phentolamine on basal and pethidine-induced inhibition of gastric emptying in healthy volunteers.

  • O. U. Petring
  • Medicine, Chemistry
    British journal of clinical pharmacology
  • 1989
1. The effect of phentolamine 5 mg i.v. on basal and pethidine-induced inhibition of gastric emptying of semisolid TC-99m labelled Chelex-100 resin/oatmeal was studied in ten healthy volunteers. 2.

Zacopride, a potent 5‐HT3 antagonist

It is concluded that zacopride possesses 5‐HT3 receptor antagonizing properties and was found to antagonize competitively the effects of 5‐hydroxytryptamine on the guinea‐pig ileum, the rabbit vagus nerve and the von Bezold Jarisch reflex in the rat.

Cisplatin-induced emesis: systematic review and meta-analysis of the ferret model and the effects of 5-HT3 receptor antagonists

It is revealed that the efficacy of ondansetron is similar against low and high doses of cisplatin, and 5-HT3 receptor antagonists have a similar efficacy during acute and delayedEmesis, which provides a novel insight into the pharmacology of delayed emesis in the ferret.

Dopamine and Gastrointestinal Motility

In pathological states, such as Parkinson’s disease (PD), the symptoms and underlying mechanism of abnormalGI motility in PD patients are summarized, and the possible mode of DA in GI motility regulation is discussed, via acting on smooth muscle cells, intrinsic neurons, and extrinsic neurons.

New Alkoxypyridine-sulfonamides: Synthesis, Biological Evaluation, and Physicochemical Properties

As a further phanmacomodulation of benzamide derivatives, two structural modifications were introduced by synthesizing pyridinesulfonamides 5 and 6, whereby the sp3 character of the sulfonamide N-atom of 6 modifies the relative spatial orientation of one substituent in relation to each of the others.



Interaction between serotonin and morphine in the guinea-pig ileum.

5-HT may play an essential role in the mechanism by which morphine induces analgesia in the central nervous system, as shown in the example of guinea-pig ileum inhibition.

Two types of receptors for 5‐hydroxytryptamine on the cholinergic nerves of the guinea‐pig myenteric plexus

The results suggest that the excitatory 5‐ HT receptor (‘M’‐receptor) differs in its pharmacological properties from other neuronal 5‐HT receptors.