The action of cysteinyl-leukotrienes on intracellular calcium mobilization in human detrusor myocytes.

@article{Bouchelouche2001TheAO,
  title={The action of cysteinyl-leukotrienes on intracellular calcium mobilization in human detrusor myocytes.},
  author={Kirsten Bouchelouche and Thomas Horn and J\orgen Nordling and Shaun Larsen and Tage Hald},
  journal={BJU international},
  year={2001},
  volume={87 7},
  pages={690-6}
}
OBJECTIVE To investigate the presence of leukotriene D4 receptors in fura-2-loaded human detrusor smooth muscle cells (DSMCs) by examining the ability of leukotriene D4 to raise intracellular-free Ca2+ concentration ([Ca2+]i), to determine the origin of the leukotriene D4-mediated rise in [Ca2+]i and to investigate whether the specific leukotriene D4 receptor antagonist montelukast inhibits the Ca2+ response induced by leukotriene D4. MATERIALS AND METHODS Detrusor muscle biopsies were… CONTINUE READING