The action of cisapride on gastric emptying and the pharmacodynamics and pharmacokinetics of oral diazepam

  title={The action of cisapride on gastric emptying and the pharmacodynamics and pharmacokinetics of oral diazepam},
  author={D. Bateman},
  journal={European Journal of Clinical Pharmacology},
  • D. Bateman
  • Published 2004
  • Medicine
  • European Journal of Clinical Pharmacology
SummaryThe effects of the benzamide cisapride (C) (8 mg) i.v. have been compared to placebo (P) in a double blind randomised study. The effects on gastric emptying, the absorption and effects of oral diazepam, and BP and pulse were observed.Cisapride increased the rate of gastric emptying of 500 ml liquid containing diazepam 10 mg (t1/2 C: 7.4 min, P: 14.9 min). The initial rate of absorption of diazepam contained in the drink was increased by C (AUC 0–1 h C: 328 µg h 1−1, P: 253 µg h 1−1, but… Expand
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