The action of cholinomimetic substances on impulse conduction in the habenulointerpeduncular pathway of the rat in vitro.

  title={The action of cholinomimetic substances on impulse conduction in the habenulointerpeduncular pathway of the rat in vitro.},
  author={D. A. Brown and R. J. Docherty and J. V. Halliwell},
  journal={The Journal of Physiology},
The effects of some cholinomimetic substances and their antagonists on the peak height of compound action potentials recorded from the terminal region of the habenulointerpeduncular pathway have been studied using a rat brain slice preparation. Carbachol and acetylcholine (ACh) depressed the peak height of the compound action potential and increased the latency to peak. The nicotinic agonists nicotine and dimethylphenylpiperazinium depressed the peak height of the compound action potential… 

Acetylcholine causes rapid nicotinic excitation in the medial habenular nucleus of guinea pig, in vitro

  • D. McCormickD. Prince
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1987
Intracellular recordings revealed that ACh or nicotine cause an increase in membrane conductance associated with depolarizations that had an average reversal potential of -16 to -11 mV, suggesting that cholinergic transmission in the MHb may be largely of the nicotinic type.

Muscarinic Cholinergic Inhibition of Glutamatergic Transmission

The effects of ACh on postsynaptic membrane currents have been more fully analyzed and it is demonstrated that this excitatory effect to be associated with a depolarization and a decrease in potassium conductance is in contrast to the depressant effects of muscarinic agonists observed on evoked synaptic activity.

Existence of different subtypes of nicotinic acetylcholine receptors in the rat habenulo-interpeduncular system

In contrast, nAChRs recorded on the soma of MHB neurons under equivalent experimental conditions exhibited different characteristics for single-channel conductance and agonist and antagonist sensitivity, demonstrating the functional diversity of nA ChRs in the rat CNS.

Participation of cholinergic mechanisms in the origination of the dendritic potential of the cerebral cortex

The influence of a series of muscarinic and nicotinic substances on the dendritic potentials of the cerebral cortex was studied in acute experiments on adult cats under deep nembutal anesthesia and it is hypothesized that there are postsynaptic M-cholinoreceptors of the M1 type, presynaptic M/N type, and Presynaptic N/N types in the neuropil of layer I of the cortex.

Autoradiographical Evidence of Nicotinic Receptors in Rat Brain

Many biochemical, electrophysiological, and behavioral studies have demonstrated central actions of nicotine that are blocked by nicotinic antagonists, and some of these actions are known to be stereoselective (6,7,8).

Role of Ca2+ Ions in Nicotinic Facilitation of GABA Release in Mouse Thalamus

It is proposed that the nicotinic facilitation of GABAergic transmission may contribute to the increase of signal-to-noise ratio observed in the thalamus in vivo during arousal.



Chemical transmission in the rat interpeduncular nucleus in vitro.

It is concluded that ACh is an unlikely candidate for transmitter in this pathway despite abundant neurochemical evidence in its favour and it is more likely that the transmitter is an excitatory amino acid, probably an aspartate‐like substance.

The excitant action of acetylcholine and other substances on cutaneous sensory pathways and its prevention by hexamethonium and d‐tubocurarine

The experiments described in this paper show that a-lobeline, like acetylcholine and nicotine, can excite a discharge in sensory fibres from the skin; and that hexamethonium and D-tubocurarine prevent the excitant effect of this group of drugs without influencing the normal touch response.

The action of acetylcholine and some related substances on conduction in mammalian non‐myelinated nerve fibres

The aim of the present experiments was to determine to what extent the action ofacetylcholine on mammalian non-myelinated fibres is common to other cholinesters, to choline itself and to some alkaloids which are pharmacologically related to acetyl choline.

The action of acetylcholine on conduction in mammalian non‐myelinated fibres and its prevention by anticholinesterase

The present experiments use a technique more suited to this particular problem and deal with the action of acetylcholine on non-myelinated fibres in isolated mammalian nerves.

Confirmation from choline acetylase analyses of a massive cholinergic innervation to the rat hippocampus

Unilateral lesions were made in the fimbria of adult rats with a stereotaxically‐applied, radio‐frequency current to assess choline acetylase (ChAc) activity and stained histochemically for acetylcholinesterase (AChE) activity.