The action of anaesthetics and high pressure on neuronal discharge patterns.

@article{Wann1992TheAO,
  title={The action of anaesthetics and high pressure on neuronal discharge patterns.},
  author={Kenneth T. Wann and Andrew P. Southan},
  journal={General pharmacology},
  year={1992},
  volume={23 6},
  pages={
          993-1004
        }
}
1. The membrane actions of both anaesthetics and high pressure have been studied in rat hippocampal slices in experiments where either field potential (orthodromic or antidromic) responses from the CA1 region are recorded or intracellular measurements in CA1 neurones are made. 2. It is clear that anaesthetics have multiple post-synaptic actions in CA1 pyramidal neurones. For example, the amplitude of antidromic field potential responses are depressed (e.g. 2.5% enflurane) or increased (20 mM… CONTINUE READING

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