[The action of adrenergic agonists and antagonists on kidney function and arterial pressure depending on the mineral component of the diet].

Abstract

The experiments on rats showed that high consumption of sodium chloride promotes the diuretic action of phenylephrine (mesaton), the alpha-adrenergic agonist, and prolong its pressor effect. In supplementation of diet with sanasol and hyposol, a new substitute of common salt, phenylephrine, causes the renal effects typical of beta-adrenoceptor stimulation. Both the sanasol and especially hyposol decrease the strength and duration of phenylephrine pressor action and increase the duration of isadrine depressor effect. Thus, the reactivity of alpha- and beta-adrenergic mechanisms depend on the mineral composition of diet, which is able to change the pharmacodynamics of cardiovascular agents.

Cite this paper

@article{Shtrygol1995TheAO, title={[The action of adrenergic agonists and antagonists on kidney function and arterial pressure depending on the mineral component of the diet].}, author={S Iu Shtrygol' and L. L. Branchevskii}, journal={Eksperimental'naia i klinicheskaia farmakologiia}, year={1995}, volume={58 5}, pages={31-3} }