The action of a urea—lactic acid ointment in ichthyosis

@article{Blair1976TheAO,
  title={The action of a urea—lactic acid ointment in ichthyosis},
  author={C P Blair},
  journal={British Journal of Dermatology},
  year={1976},
  volume={94}
}
  • C. Blair
  • Published 1 February 1976
  • Chemistry, Medicine
  • British Journal of Dermatology
The effect of urea—lactic acid ointment on the scales of ichthyotic skin was assessed using the ‘cell swelling’ technique of Christophers & Kligman. The thickness of the horny layer and of the scales was reduced both by the ointment and by the base. The formation of scales was shown to differ from that in psoriasis where the scale forms at the apex of a rete peg and is symmetrical whereas in ichthyosis the separation of the scale may be at an entirely different depth at one margin. There is an… 
Ichthyosis and dry skin *
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In this short review of the history of ichthyosis, only those aspects of the subject which can be regarded as advances or growing points are included which offer the prospect of major steps forward in the management of the disease.
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  • Medicine
    American journal of clinical dermatology
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In double-blind studies moisturizers with urea have been shown to reduce TEWL in atopic and ichthyotic patients and ceramide-dominant lipid mixture improved atopic dermatitis and decreased transepidermal water loss in an open-label study in children.
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  • T. Dirschka
  • Medicine
    International journal of clinical practice
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TLDR
Biophysical characteristics and properties of molecular biology that explain how urea affects healthy skin and exerts efficacy in various skin diseases are elucidated.
Effect of moisturizers on epidermal barrier function.
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TLDR
Moisturizers that reduce the signs of dryness and strengthen skin barrier function are believed to also reduce the prevalence of inflammatory dermatosis.
The ichthyoses--a review.
  • R. Rand, H. Baden
  • Medicine
    Journal of the American Academy of Dermatology
  • 1983
Fruit acid extracts, a fresh approach to skin renewal
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The history of alpha‐hydroxy acids use in cosmetics is reviewed and new data showing the increased rate of cell renewal by topical application is given.
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References

SHOWING 1-10 OF 20 REFERENCES
ASPECTS OF THE ANATOMY AND PHYSIOLOGY OF THE SKIN OF THE HIPPOPOTAMUS (H. AMPHIBIUS).
  • C. P. Luck, P. Wright
  • Biology, Medicine
    Quarterly journal of experimental physiology and cognate medical sciences
  • 1964
TLDR
A more detailed study of the hippopotamus's skin shows that its structure, while probably primarily one of many possible modifications for an aquatic environment, permits a rate of transepidermal water loss that is greater than that in other animals for which figures can be obtained.
Histology of autosomal dominant ichthyosis vulgaris and X-linked ichthyosis.
TLDR
The histology of autosomal dominant ichthyosis vulgaris and X-linked ICHthyosis was studied using biopsy material from the arm and leg and found that specimens are obtained from regions of maximal scaling.
CELL REPLACEMENT IN THE HUMAN STRATUM CORNEUM IN OLD AGE
SUMMARY. Staining of the human stratum corneum in vivo with fluorescent tetrachlorsalicylanilide has been used to measure the transit time of horny cells in the normal forearm skin of aged people.
The histology of ichthyosis.
TLDR
The histology of sex-linked ichthyosis is very similar to that of non-bullous ichmalosiform erythrodermia, and the histological features that distinguished each inherited variety were described.
VISUALIZATION OF THE CELL LAYERS OF THE STRATUM CORNEUM.
TLDR
The anatomy of the horny layer is usually spoiled beyond recognition by tissue processing, whereas in fact it is a coherent, plastic membrane which serves as the ''barrier against the inward and outward movement of all substances including water''.
MORPHOLOGY AND THICKNESS OF THE HUMAN STRATUM CORNEUM
  • C. Blair
  • Chemistry, Medicine
    The British journal of dermatology
  • 1968
SUMMARY.— The method of exhibiting the layers of cells of the stratum corneum described by Kligman and Christophers has been employed and elaborated, and has proved to be practical and reproducible.
Ordered Structure of the Stratum Corneum of Mammalian Skin
TLDR
The boundaries of the cells of the stratum corneum can be clearly seen after treating unfixed sections with sodium hydroxide solution, because this causes the strata corneum to swell but leaves the cell membranes of this layer intact.
...
1
2
...