The action of TNFalpha and TGFbeta include specific alterations of the glycosylation of bovine and human chondrocytes.

@article{Yang2007TheAO,
  title={The action of TNFalpha and TGFbeta include specific alterations of the glycosylation of bovine and human chondrocytes.},
  author={Xiaojing Yang and Jana C Yip and Tassos P. Anastassiades and Mark S. Harrison and Inka Brockhausen},
  journal={Biochimica et biophysica acta},
  year={2007},
  volume={1773 2},
  pages={264-72}
}
Joint destruction in arthritis is often associated with high levels of inflammatory cytokines. Previous work has shown that inflammatory conditions can alter the activities of glycosyltransferases that synthesize the glycan chains of glycoproteins, and that these changes in turn can influence the functions of glycoproteins. We therefore examined glycosyltransferases involved in glycoprotein biosynthesis in primary cultures of bovine articular chondrocytes and human chondrocytes isolated from… CONTINUE READING

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