The action of (S)-alpha-chlorohydrin and 6-chloro-6-deoxyglucose on the metabolism of guinea pig spermatozoa.

@article{Jones1984TheAO,
  title={The action of (S)-alpha-chlorohydrin and 6-chloro-6-deoxyglucose on the metabolism of guinea pig spermatozoa.},
  author={A. Jones and S. A. Ford},
  journal={Contraception},
  year={1984},
  volume={30 3},
  pages={
          261-9
        }
}
  • A. Jones, S. A. Ford
  • Published 1984
  • Biology, Medicine
  • Contraception
  • (S)-alpha-Chlorohydrin inhibits the conversion of fructose to lactate by mature guinea pig spermatozoa in vitro. At a concentration of 2mM, there is a specific inhibition of glyceraldehyde-phosphate dehydrogenase resulting in the accumulation of fructose-1,6-bisphosphate, dihydroxyacetone phosphate and glyceraldehyde-3-phosphate and a concomitant decrease in the concentration of endogenous lactate. (R,S)-[3-36Cl]-alpha-Chlorohydrin is metabolised by the spermatozoa to 3-chlorolactaldehyde of… CONTINUE READING
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    The selective neurotoxicity produced by 3-chloropropanediol in the rat is not a result of energy deprivation.
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