# The action of γ-Aminobutyric acid on cortical neurones

@article{Krnjevic2004TheAO,
title={The action of $\gamma$-Aminobutyric acid on cortical neurones},
author={Kresimir Krnjević and Susan Schwartz},
journal={Experimental Brain Research},
year={2004},
volume={3},
pages={320-336}
}
• Published 2004
• Biology
• Experimental Brain Research
SummaryIn cats under pentobarbitone anaesthesia, GABA was tested on cortical, pericruciate neurones and its action compared with IPSPs evoked by surface stimulation. GABA was applied to individual cells by microiontophoresis, while recording the membrane potential and resistance. When K citrate-recording electrodes were used, GABA always hyperpolarized the cell and lowered its resistance, like the synaptic inhibitory effect. By adequate polarization both the action of GABA and the IPSP could be…

### Interaction of penicillin and pentobarbital with inhibitory synaptic mechanisms in neocortex

• Biology
Cellular and Molecular Neurobiology
• 2004
The results suggest that the convulsant penicillin and the anticonvulsant pentobarbital have opposing actions on GABAergic inhibition in the neocortex.

### Cortical inhibition and γ-aminobutyric acid

• Biology
Experimental Brain Research
• 2004
Previous evidence of a close identity between the actions of GABA and of the normal transmitter of cortical IPSPs is greatly reinforced, probably owing to a large influx of Cl−.

### The inhibition of retinal ganglion cells by catecholeamines and γ-aminobutyric acid

• Biology
Pflügers Archiv
• 2004
l-Dopa, the metabolic precursor of Dopamine, was found to depress the amplitude of the evoked potential in the optic tract, when applied intravenously, and substances suspected to be transmitters by virtue of their presence in the retina are shown to produce the expected pharmacological effects.

### Actions of amino acids and convulsants on bulbar reticular neurones

• Biology
Experimental Brain Research
• 2004
A comparison of the results with those obtained in the spinal cord provides some evidence that glycine may be an inhibitory transmitter substance released on bulbar reticular neurones.

### Action of γ-aminobutyric acid and glycine on red nucleus neurones

• Biology
Pflügers Archiv
• 2004
GABA and glycine were applied iontophoretically in the red nucleus and their effects were tested upon focal potentials in extracellular records, and upon the cell membrane of rubrospinal neurons in intracellular records.

### Effect of substances modifyingγ-aminobutyric acid metabolism on recovery cycles of the interzonal response of the cat motor cortex

• Biology
Bulletin of Experimental Biology and Medicine
• 2004
It is suggested that the facilitation described above is the result of interaction between systems of recurrent excitation and inhibition, and GABA plays an important role in the regulation of this interaction.

### Role of γ-aminobutyric acid (GABA) in the extrapyramidal motor system

• Biology
Experimental Brain Research
• 2004
SummaryInterference with the neuronal connection between the substantia nigra and striatum of rat by hemitransection at the subthalamic level or lesion of left side of striatum by a simple suction

### The hyperpolarization of spinal motoneurones by glycine and related amino acids

• Biology
Experimental Brain Research
• 2004
The results indicate that glycine may be a major spinal inhibitory transmitter, in which case strychnine affects spinal postsynaptic inhibition by limiting the action of glycine upon subsynaptic inhibitory receptors.

### Some properties of unresponsive cells in the cerebral cortex

• Biology
Experimental Brain Research
• 2004
It is suggested that unresponsive cells are neuroglia; that the depolarizing actions of GABA and ACh indicate a change in electrogenic active transport, and that glia may remove transmitters from the extracellular space.

### Keeping the Balance: GABAB Receptors in the Developing Brain and Beyond

Given their subunit composition and their ability to form complexes with several associated proteins, GABABRs display heterogeneity with regard to their function, which makes them a promising target for pharmacological interventions.

## References

SHOWING 1-10 OF 26 REFERENCES

### Some properties of unresponsive cells in the cerebral cortex

• Biology
Experimental Brain Research
• 2004
It is suggested that unresponsive cells are neuroglia; that the depolarizing actions of GABA and ACh indicate a change in electrogenic active transport, and that glia may remove transmitters from the extracellular space.

### Iontophoretic studies of neurones in the mammalian cerebral cortex

• Biology
The Journal of physiology
• 1963
Iontophoresis has been used extensively in experiments on spinal neurones and also in two studies of neurones in the brain stem, and is the method of choice whenever the substance is ionized in solution.

### The depression of spinal neurones by γ‐amino‐n‐butyric acid and β‐alanine

• Biology
• 1959
The present investigation has been carried out in order to determine the effect of GABA and substances of related structure upon neurones within the spinal cord of the cat.

### Intracelluläre Reizung corticaler Nervenzellen

• Biology
Pflüger's Archiv für die gesamte Physiologie des Menschen und der Tiere
• 2004
Advertising of firing during long pulses seems to be a process which appears only if the firing level is reached or surpassed, and accommodation to linearly rising transmembranous currents is absent or negligible in cortical cells.

### THE EXCITATION AND DEPRESSION OF MAMMALIAN CORTICAL NEURONES BY AMINO ACIDS.

• Biology, Chemistry
British journal of pharmacology and chemotherapy
• 1964
Amino acids related to L-glutamic and gamma-amino-n-butyric acid have been administered electrophoretically, and by pressure ejection, into the extraneuronal environment of single neurones in the

### The action of the neuromuscular transmitter on the slow fibre membrane

• Biology
The Journal of physiology
• 1956
An attempt has been made to find out whether the same type of process is responsible for the small-nerve junctional potential (s.j.p.) in slow fibres by superimposing it on different steady electrotonic potentials.

### Cortical motor threshold and the thresholds and distribution of excited Betz cells in the cat.

• C. G. Phillips
• Biology
Quarterly journal of experimental physiology and cognate medical sciences
• 1956
It is concluded that in punctate stimulation of the cat's motor cortex with single 10 msec.

### Determination of iontophoretic release of acetylcholine from micropipettes

• Biology
The Journal of physiology
• 1963
Some properties of single and multibarrelled micropipettes which contained strong solutions of acetylcholine (ACh) were examined, and measurements were done of the amounts of ACh released in vitro under conditions approximating as nearly as possible to those in physiological experiments.

### STRUCTURE‐ACTIVITY DETERMINANTS OF PHARMACOLOGICAL EFFECTS OF AMINO ACIDS AND RELATED COMPOUNDS ON CENTRAL SYNAPSES

• Biology
Journal of neurochemistry
• 1959
The conceptual basis of the work described here rests upon the demonstration that the major electrocortical activity in cat brain by various means of activating the cerebral or cerebellar cortex is composed of postsynaptic potentials (p.p.s.’s) of the superficial dendrites.