The action of γ-Aminobutyric acid on cortical neurones

@article{Krnjevic2004TheAO,
  title={The action of $\gamma$-Aminobutyric acid on cortical neurones},
  author={K. Krnjević and S. Schwartz},
  journal={Experimental Brain Research},
  year={2004},
  volume={3},
  pages={320-336}
}
SummaryIn cats under pentobarbitone anaesthesia, GABA was tested on cortical, pericruciate neurones and its action compared with IPSPs evoked by surface stimulation. GABA was applied to individual cells by microiontophoresis, while recording the membrane potential and resistance. When K citrate-recording electrodes were used, GABA always hyperpolarized the cell and lowered its resistance, like the synaptic inhibitory effect. By adequate polarization both the action of GABA and the IPSP could be… Expand
Interaction of penicillin and pentobarbital with inhibitory synaptic mechanisms in neocortex
TLDR
The results suggest that the convulsant penicillin and the anticonvulsant pentobarbital have opposing actions on GABAergic inhibition in the neocortex. Expand
Cortical inhibition and γ-aminobutyric acid
Summary1.In cats under Dial, multiple micro-electrodes were used to analyze the changes in membrane potential and conductance of cortical neurones produced by inhibition (evoked by surface shocks)Expand
The inhibition of retinal ganglion cells by catecholeamines and γ-aminobutyric acid
TLDR
l-Dopa, the metabolic precursor of Dopamine, was found to depress the amplitude of the evoked potential in the optic tract, when applied intravenously, and substances suspected to be transmitters by virtue of their presence in the retina are shown to produce the expected pharmacological effects. Expand
Actions of amino acids and convulsants on bulbar reticular neurones
TLDR
A comparison of the results with those obtained in the spinal cord provides some evidence that glycine may be an inhibitory transmitter substance released on bulbar reticular neurones. Expand
Action of γ-aminobutyric acid and glycine on red nucleus neurones
TLDR
GABA and glycine were applied iontophoretically in the red nucleus and their effects were tested upon focal potentials in extracellular records, and upon the cell membrane of rubrospinal neurons in intracellular records. Expand
Effect of substances modifyingγ-aminobutyric acid metabolism on recovery cycles of the interzonal response of the cat motor cortex
TLDR
It is suggested that the facilitation described above is the result of interaction between systems of recurrent excitation and inhibition, and GABA plays an important role in the regulation of this interaction. Expand
Role of γ-aminobutyric acid (GABA) in the extrapyramidal motor system
SummaryInterference with the neuronal connection between the substantia nigra and striatum of rat by hemitransection at the subthalamic level or lesion of left side of striatum by a simple suctionExpand
The hyperpolarization of spinal motoneurones by glycine and related amino acids
TLDR
The results indicate that glycine may be a major spinal inhibitory transmitter, in which case strychnine affects spinal postsynaptic inhibition by limiting the action of glycine upon subsynaptic inhibitory receptors. Expand
Some properties of unresponsive cells in the cerebral cortex
TLDR
It is suggested that unresponsive cells are neuroglia; that the depolarizing actions of GABA and ACh indicate a change in electrogenic active transport, and that glia may remove transmitters from the extracellular space. Expand
Chapter 9 – The ionotropic GABAA receptor
TLDR
The aim of the present chapter is to study how a GABA A receptor converts the binding of two GABA molecules to a rapid and transient change of the membrane potential in the adult vertebrate central nervous system. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 29 REFERENCES
Some properties of unresponsive cells in the cerebral cortex
TLDR
It is suggested that unresponsive cells are neuroglia; that the depolarizing actions of GABA and ACh indicate a change in electrogenic active transport, and that glia may remove transmitters from the extracellular space. Expand
The non‐selective blocking action of γ‐aminobutyric acid on the sensory cerebral cortex of the rat
y-Aminobutyric acid can be easily extracted from various parts of the nervous system and since it has been shown to have inhibitory effects on the activity of neurones, interest has centred upon itsExpand
MICRO-IONTOPHORETIC STUDIES ON CORTICAL NEURONS.
  • K. Krnjević
  • Biology, Medicine
  • International review of neurobiology
  • 1964
TLDR
This chapter discusses the micro-iontophoretic studies on cortical neurons in mammals, which were first used systematically for investigations on neurons in the central nervous system (CNS) in their analysis of the cholinergic synapses on Renshaw cells in the spinal cord. Expand
Iontophoretic studies of neurones in the mammalian cerebral cortex
TLDR
Iontophoresis has been used extensively in experiments on spinal neurones and also in two studies of neurones in the brain stem, and is the method of choice whenever the substance is ionized in solution. Expand
The depression of spinal neurones by γ‐amino‐n‐butyric acid and β‐alanine
It is now generally accepted that the processes of synaptic excitation and inhibition within the mammalian nervous system are chemical in nature (cf. Fatt, 1954; Eccles, 1957). It may therefore beExpand
Intracelluläre Reizung corticaler Nervenzellen
Abstract1. Intracellular records were taken from pyramidal cells of the pericruciate gyrus of anesthetized cats. Action potentials of cortical neurons do not always show an IS/SD break, but areExpand
THE EXCITATION AND DEPRESSION OF MAMMALIAN CORTICAL NEURONES BY AMINO ACIDS.
Amino acids related to L-glutamic and gamma-amino-n-butyric acid have been administered electrophoretically, and by pressure ejection, into the extraneuronal environment of single neurones in theExpand
Response of single motoneurons to direct stimulation in toad's spinal cord.
TLDR
The results reported here were obtained with a method of direct stimulation of single spinal motoneurons of Japanese toads using the same microelectrode with certain compensation circuits for both stimulation and recording. Expand
The action of the neuromuscular transmitter on the slow fibre membrane
TLDR
An attempt has been made to find out whether the same type of process is responsible for the small-nerve junctional potential (s.j.p.) in slow fibres by superimposing it on different steady electrotonic potentials. Expand
Cortical motor threshold and the thresholds and distribution of excited Betz cells in the cat.
  • C. G. Phillips
  • Biology, Medicine
  • Quarterly journal of experimental physiology and cognate medical sciences
  • 1956
TLDR
It is concluded that in punctate stimulation of the cat's motor cortex with single 10 msec. Expand
...
1
2
3
...