The actin nucleator Cobl is crucial for Purkinje cell development and works in close conjunction with the F-actin binding protein Abp1.

Abstract

Cortical actin dynamics shapes cells. To generate actin filaments, cells rely on actin nucleators. Cobl is a novel, brain-enriched, WH2 domain-based actin nucleator, yet, its functions remained largely elusive. Here, we reveal that Cobl plays a crucial role in Purkinje cell development using gene gun transfections within intact murine cerebellar contexts… (More)
DOI: 10.1523/JNEUROSCI.0843-12.2012

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@article{Haag2012TheAN, title={The actin nucleator Cobl is crucial for Purkinje cell development and works in close conjunction with the F-actin binding protein Abp1.}, author={Natja Haag and Lukas Schwintzer and Rashmi Ahuja and Nicole Koch and Julia Grimm and Heike Heuer and Britta Qualmann and Michael M Kessels}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={2012}, volume={32 49}, pages={17842-56} }