The actin-myosin cytoskeleton mediates reversible agonist-induced membrane blebbing.

@article{Torgerson1998TheAC,
  title={The actin-myosin cytoskeleton mediates reversible agonist-induced membrane blebbing.},
  author={Rochelle R. Torgerson and Mark A. McNiven},
  journal={Journal of cell science},
  year={1998},
  volume={111 ( Pt 19)},
  pages={2911-22}
}
Suprastimulation of pancreatic acinar cells with specific agonists inhibits zymogen secretion and induces the formation of large basolateral blebs. Currently the molecular mechanisms that mediate this dramatic morphologic response are undefined. Further, it is unclear if blebbing represents a terminal or reversible event. Using computer-enhanced video microscopy of living acini we have found that these large blebs form rapidly (within 2-3 minutes) and exhibit ameboid undulations. They are… CONTINUE READING