The actin-like MreB cytoskeleton organizes viral DNA replication in bacteria.

@article{MuozEspn2009TheAM,
  title={The actin-like MreB cytoskeleton organizes viral DNA replication in bacteria.},
  author={Daniel Mu{\~n}oz-Esp{\'i}n and Richard Menduwas Daniel and Yoshikazu Kawai and Rut Carballido-L{\'o}pez and Virginia Castilla-Llorente and Jeff Errington and Wilfried J J Meijer and M. Salas},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 32},
  pages={
          13347-52
        }
}
Little is known about the organization or proteins involved in membrane-associated replication of prokaryotic genomes. Here we show that the actin-like MreB cytoskeleton of the distantly related bacteria Escherichia coli and Bacillus subtilis is required for efficient viral DNA replication. Detailed analyses of B. subtilis phage ϕ29 showed that the MreB cytoskeleton plays a crucial role in organizing phage DNA replication at the membrane. Thus, phage double-stranded DNA and components of the… CONTINUE READING

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