The actin cytoskeleton reorganization induced by Rac1 requires the production of superoxide.

@article{Moldovan1999TheAC,
  title={The actin cytoskeleton reorganization induced by Rac1 requires the production of superoxide.},
  author={Leni Moldovan and Kaikobad Irani and Nicanor I. Moldovan and Toren Finkel and Pascal J. Goldschmidt-Clermont},
  journal={Antioxidants & redox signaling},
  year={1999},
  volume={1 1},
  pages={29-43}
}
The small GTPase rac1 controls actin redistribution to membrane ruffles in fibroblasts and other cell types, as well as the activation of the NADPH oxidase in phagocytes. We explored the possibility that these two processes could be related. We used a replication-deficient adenoviral vector to overexpress the constitutively active form of rac1, racV12, in human and mouse aortic endothelial cells. We show here that, in addition to membrane ruffle formation, racV12 induced an increase in the… CONTINUE READING

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