The acquired immunodeficiency syndrome in persons with hemophilia.

  title={The acquired immunodeficiency syndrome in persons with hemophilia.},
  author={Paul H. Levine},
  journal={Annals of internal medicine},
  volume={103 5},
The widespread use of coagulation factor concentrates prepared from the blood of numerous donors has doubled the life expectancy of persons with hemophilia, but parenteral exposure to alloantigens and infectious agents is not free of risk. The prevalence of the acquired immunodeficiency syndrome (AIDS) now approaches 1% in patients with hemophilia, and laboratory evidence of abnormal immunoregulation is found in at least 50% of treated patients with severe hemophilia. The immune defect is… CONTINUE READING

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