The acquired immunodeficiency syndrome in a cohort of homosexual men. A six-year follow-up study.

@article{Jaffe1985TheAI,
  title={The acquired immunodeficiency syndrome in a cohort of homosexual men. A six-year follow-up study.},
  author={Harold W. Jaffe and William W. Darrow and Dean F. Echenberg and Paul M. O'Malley and Jane P. Getchell and Vaniambadi S. Kalyanaraman and Robert H. Byers and D P Drennan and Erwin H. Braff and James W. Curran},
  journal={Annals of internal medicine},
  year={1985},
  volume={103 2},
  pages={
          210-4
        }
}
A cohort of 6875 homosexual men, initially seen at the San Francisco City Clinic between 1978 and 1980, were studied to determine the incidence and prevalence of the acquired immunodeficiency syndrome, related conditions, and infection with the human T-lymphotropic virus, type III/lymphadenopathy-associated virus (HTLV-III/LAV). By December 1984, 2.4% of the men had the syndrome; mortality attributable to the syndrome in 1984 was 600/100 000. For each man with the syndrome in a representative… 
Predictors of the acquired immunodeficiency syndrome developing in a cohort of seropositive homosexual men.
In a cohort of 1835 homosexual men who were seropositive for human immunodeficiency virus (HIV) on entry into a prospective study, the acquired immunodeficiency syndrome (AIDS) developed in 59 during
Human T-cell lymphotropic virus type III infection in a cohort of homosexual men in New York City.
TLDR
The continuing risk of HTLV-III infections in the homosexual population studied is demonstrated and the need for more effective prevention of transmission is emphasized.
Risk of developing AIDS in HIV-infected cohorts of hemophilic and homosexual men.
TLDR
The results suggest that currently the relative length of human immunodeficiency virus infection is of primary importance in comparing disease outcome for different populations.
Course of HIV-I infection in a cohort of homosexual and bisexual men: an 11 year follow up study.
TLDR
Cumulative risk of AIDS by duration of HIV-I infection was analysed for all 489 men by the Kaplan-Meier method and confirmed the importance of duration of infection to clinical state and the high risk ofAIDS after infection.
Natural history of acquired immunodeficiency syndrome in hemophilic patients
TLDR
It is suggested that the incubation period of AIDS is considerably long and that prospective study of serial immunologic markers and HTLV‐III markers may be warranted in hemophilic patients at risk.
Three-year incidence of AIDS in five cohorts of HTLV-III-infected risk group members.
TLDR
Five subjects followed for a mean of 31 months after documented seroconversion developed AIDS 28 to 62 months after the estimated date of seroconverted, supporting the hypothesis that there is a long latency between acquisition of viral infection and the development of clinical AIDS.
Risk factors for human immunodeficiency virus (HIV) infections in homosexual men.
TLDR
In multivariate analyses, receptive anal intercourse with ejaculation by nonsteady sexual partners, many sexual partners per month, and other indicators of high levels of sexual activity were highly associated with seroconversions, and none of the sexual practices appeared to offer protection against HIV infection.
NATURAL HISTORY OF HUMAN IMMUNODEFICIENCY VIRUS INFECTION IN ZAIRE
TLDR
These data provide the first estimates for rates of progression to AIDS or AIDS-related conditions among healthy HIV seropositive heterosexual adults and are similar to those reported in US or European homosexual or bisexual men.
Human immunodeficiency virus type 1 infection in homosexual men who remain seronegative for prolonged periods.
Abstract Infection with the human immunodeficiency virus type 1 (HIV-1), as demonstrated by viral cultures, has been described in some patients before antibodies to HIV–1 can be detected, but the
The epidemiology and prevention of the acquired immunodeficiency syndrome.
  • J. Curran
  • Medicine
    Annals of internal medicine
  • 1985
TLDR
Preventing transmission among sexual partners, among intravenous drug users, and from infected mothers to newborns will continue to be difficult without a vaccine, specific antiviral therapy, or both.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 31 REFERENCES
Seroepidemiology of HTLV-III antibody in Danish homosexual men: prevalence, transmission, and disease outcome.
TLDR
The spread of HTLV-III from high to low risk areas and the subsequent appearance of illnesses related to AIDS in the seropositive group support the hypothesis that HTLV -III is causally related to the development of AIDS.
DETERMINANTS OF RETROVIRUS (HTLV-III) ANTIBODY AND IMMUNODEFICIENCY CONDITIONS IN HOMOSEXUAL MEN
TLDR
The data suggest that frequent receptive anal intercourse with many homosexual partners predisposes to HTLV-III infection with the consequent emergence of lymphadenopathy and the various manifestations of lesser and fully fledged AIDS.
The incidence rate of acquired immunodeficiency syndrome in selected populations.
Population figures were obtained, and incidence rates of acquired immunodeficiency syndrome (AIDS) for the 12 months from June 1, 1983, to May 31, 1984, were estimated for single (never-married) men
LONGITUDINAL STUDY OF PERSISTENT GENERALISED LYMPHADENOPATHY IN HOMOSEXUAL MEN: RELATION TO ACQUIRED IMMUNODEFICIENCY SYNDROME
TLDR
A lower mean absolute helper T cell count and an increased frequency of anergy to mumps intradermal antigen and of herpes simplex virus isolation distinguished these patients from those remaining in the cohort, who seem to be stable and in some cases to have improved.
Acquired immune deficiency syndrome (AIDS) trends in the United States, 1978-1982.
TLDR
Surveillance has been predominantly passive, supplemented by active follow-up of requests to the Centers for Disease Control for pentamidine isethionate for treatment of Pneumocystis carinii pneumonia.
Generalized lymphadenopathy in homosexual men.
TLDR
It is suggested that generalized lymphadenopathy is part of the spectrum of a disorder manifested by acquired immunodeficiency, opportunistic infections, Kaposi's sarcoma, and malignant lymphomas.
Acquired immunodeficiency syndrome (AIDS) associated with transfusions.
TLDR
Evidence that AIDS may be transmitted in blood is strengthened by the finding that patients with transfusion-associated AIDS were more likely to be white and older than other patients with no known risk factors.
Hepatitis B in homosexual men: prevalence of infection and factors related to transmission.
Of 3,816 homosexual men examined in five sexually transmitted disease clinics in the United States, 6.1% had hepatitis B surface antigen, 52.4% had antibody to hepatitis B surface antigen, and 3.0%
Oral candidiasis in high-risk patients as the initial manifestation of the acquired immunodeficiency syndrome.
TLDR
In patients at high risk for AIDS, the presence of unexplained oral candidiasis predicts the development of serious opportunistic infections more than 50 per cent of the time.
Prevalence of antibody to lymphadenopathy-associated virus among drug-detoxification patients in New York.
TLDR
Seropositive non-AIDS intravenous drug abusers from this series are being followed to determine which will acquire immunosuppression-related disease.
...
1
2
3
4
...