The acid-catalyzed solvolysis of dehydroepiandrosterone sulfate and its significance in the examination of urinary 17-ketosteroids.

@article{Segal1960TheAS,
  title={The acid-catalyzed solvolysis of dehydroepiandrosterone sulfate and its significance in the examination of urinary 17-ketosteroids.},
  author={Luc Segal and Bernard Segal and William R. Nes},
  journal={The Journal of biological chemistry},
  year={1960},
  volume={235},
  pages={3108-11}
}
Burstein and Lieberman (1) have reported a procedure for the examination of urinary ketosteroid sulfates which involves the extraction of an acidified urine with ethyl acetate followed by solvolysis of the sulfates in the organic phase at 39” for 24 hours. Although the previous authors (1) recognized that this technique partitions water and mineral acid into the ethyl acetate, they did not report a detailed examination of these factors on the rate of reaction. From kinetic evidence presented (2… CONTINUE READING