The acetyltransferase activity of CBP stimulates transcription.

  title={The acetyltransferase activity of CBP stimulates transcription.},
  author={Marian A Mart{\'i}nez-Balb{\'a}s and Andrew J. Bannister and Klaus Martin and Philipp Haus-Seuffert and Michael Meisterernst and Tony Kouzarides},
  journal={The EMBO journal},
  volume={17 10},
The CBP co-activator protein possesses an intrinsic acetyltransferase (AT) activity capable of acetylating nucleosomal histones, as well as other proteins such as the transcription factors TFIIE and TFIIF. In addition, CBP associates with two other TSs, P/CAF and SRC1. We set out to establish whether the intrinsic AT activity of CBP contributes to transcriptional activation. We show that a region of CBP, encompassing the previously defined histone AT (HAT) domain, can stimulate transcription… CONTINUE READING