The accuracy of extended histopathology to detect immunotoxic chemicals.

@article{Germolec2004TheAO,
  title={The accuracy of extended histopathology to detect immunotoxic chemicals.},
  author={Dori R. Germolec and Michael L. Kashon and Abraham Nyska and Christine F Kuper and Christopher Portier and Choudari Kommineni and Keith A. Johnson and Michael I. Luster},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2004},
  volume={82 2},
  pages={504-14}
}
The accuracy of extended histopathology to detect immunotoxic chemicals in female B6C3F1 mice was evaluated under the auspices of the National Toxicology Program (NTP). A workgroup was formed consisting of four pathologists who conducted extended histopathological evaluation of lymphoid tissues obtained from a subset of NTP toxicology studies, in which previously detailed immunotoxicity assessment was performed. In addition, a positive control data set of three known immunosuppressive agents… CONTINUE READING