The accessory helix of complexin functions by stabilizing central helix secondary structure

@inproceedings{Radoff2014TheAH,
  title={The accessory helix of complexin functions by stabilizing central helix secondary structure},
  author={Daniel T. Radoff and Yongming Dong and David B Snead and Jihong Bai and David Eliezer and Jeremy S. Dittman},
  booktitle={eLife},
  year={2014}
}
The presynaptic protein complexin (CPX) is a critical regulator of synaptic vesicle fusion, but the mechanisms underlying its regulatory effects are not well understood. Its highly conserved central helix (CH) directly binds the ternary SNARE complex and is required for all known CPX functions. The adjacent accessory helix (AH) is not conserved despite also playing an important role in CPX function, and numerous models for its mechanism have been proposed. We examined the impact of AH mutations… CONTINUE READING
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