The absorption, distribution, metabolism and excretion of rofecoxib, a potent and selective cyclooxygenase-2 inhibitor, in rats and dogs.

Abstract

Absorption, distribution, metabolism, and excretion studies were conducted in rats and dogs with rofecoxib (VIOXX, MK-0966), a potent and highly selective inhibitor of cyclooxygenase-2 (COX-2). In rats, the nonexponential decay during the terminal phase (4- to 10-h time interval) of rofecoxib plasma concentration versus time curves after i.v. or oral… (More)

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@article{Halpin2000TheAD, title={The absorption, distribution, metabolism and excretion of rofecoxib, a potent and selective cyclooxygenase-2 inhibitor, in rats and dogs.}, author={Rebecca A. Halpin and Leslie A Geer and Kaifu Zhang and Tessa Marks and D. C. Dean and Alwyn Jones and David G Melillo and Grayson A Doss and Keerti Vyas}, journal={Drug metabolism and disposition: the biological fate of chemicals}, year={2000}, volume={28 10}, pages={1244-54} }