The absorption, distribution, and excretion in mice of the antimalarial mefloquine, erythro-2,8-bis(trifluoromethyl)-alpha-(2-piperidyl)-4-quinolinemethanol hydrochloride.

@article{Rozman1978TheAD,
  title={The absorption, distribution, and excretion in mice of the antimalarial mefloquine, erythro-2,8-bis(trifluoromethyl)-alpha-(2-piperidyl)-4-quinolinemethanol hydrochloride.},
  author={Renee Rozman and N A Molek and R Koby},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1978},
  volume={6 6},
  pages={654-8}
}
Following oral administration of 14C-labeled mefloquine hydrochloride to female mice, the drug was well absorbed and distributed throughout the body. At both 24 and 48 hr after dosing the majority of radiolabel remaining in the body was in the form of parent drug. The major route of radiolabel excretion was fecal after either oral or intraperitoneal administration, with approximately 20% in the urine by 240 hr. The elimination t1/2 of unchanged drug after oral or intraperitoneal dosing was 18.7… CONTINUE READING

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