The absolute bioavailability of oral melatonin.

  title={The absolute bioavailability of oral melatonin.},
  author={R L DeMuro and Anne N. Nafziger and David E. Blask and A M Menhinick and Joseph S. Bertino},
  journal={Journal of clinical pharmacology},
  volume={40 7},
The absolute bioavailability of oral melatonin tablets was studied in 12 normal healthy volunteers. Subjects were administered, in a randomized crossover fashion, melatonin 2 mg intravenously and 2 and 4 mg orally. Blood was sampled over approximately eight (estimated) half-lives. Both the 2 and the 4 mg oral dosages showed an absolute bioavailability of approximately 15%. No difference in serum half-life was seen in any of the study phases. Oral melatonin tablets in dosages of 2 and 4 mg show… CONTINUE READING