The absolute bioavailability of clodronate from two different oral doses.

@article{Villikka2002TheAB,
  title={The absolute bioavailability of clodronate from two different oral doses.},
  author={K. Villikka and Kristiina Perttunen and J Rosnell and Harri Ik{\"a}valko and H Vaho and Liisa H Pylkk{\"a}nen},
  journal={Bone},
  year={2002},
  volume={31 3},
  pages={418-21}
}
Clodronate (disodium clodronate tetrahydrate) is a bisphosphonate used in the treatment of hypercalcemia and osteolysis due to malignancy. Like all bisphosphonates, clodronate has low and variable oral bioavailability. The purpose of this study was to examine the absolute bioavailability of clodronate from two different oral doses. Thirty-one healthy young volunteers participated in this open, randomized, three-period, single-dose, cross-over study. The absolute bioavailability was calculated… CONTINUE READING