The absolute bioavailability and effect of food on the pharmacokinetics of zolmitriptan in healthy volunteers.

@article{Seaber1998TheAB,
  title={The absolute bioavailability and effect of food on the pharmacokinetics of zolmitriptan in healthy volunteers.},
  author={E. J. Seaber and Richard Peck and Dennis A. Smith and Jane Allanson and Nanco R. Hefting and Jan Jaap van Lier and Frans A. E. Sollie and Johan Wemer and J. H. G. Jonkman},
  journal={British journal of clinical pharmacology},
  year={1998},
  volume={46 5},
  pages={433-9}
}
AIMS Zolmitriptan (Zomig (formerly 311C90)) is a novel 5-HT1B/1D receptor agonist developed for the acute oral treatment of migraine. A highly sensitive LCMS-MS assay has been developed which allows quantification of plasma concentrations of zolmitriptan and its active metabolite, 183C91, after therapeutic doses. Two studies using this assay method were conducted to investigate the pharmacokinetics, including absolute bioavailability, of 2.5 and 5 mg oral doses of zolmitriptan in men and women… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…