The absence of a functional nuclear receptor element A (NREA) in the promoter II of the aromatase P450 gene in rabbit granulosa cells

@article{Andrieu2006TheAO,
  title={The absence of a functional nuclear receptor element A (NREA) in the promoter II of the aromatase P450 gene in rabbit granulosa cells},
  author={Thomas Andrieu and Colette F{\'e}ral and Michael Joubert and Annie Benhaim and Herv{\'e} Mittre},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2006},
  volume={101},
  pages={127-135}
}
Aromatase protein is synthesized in response to gonadotropins that activate expression of their target genes via the cAMP second messenger system. The -882/+103 bp region of the rabbit ovarian promoter (PII) was ligated to a luciferase vector and transfected into granulosa cells to elucidated the mechanism by which cAMP stimulates transcription. Deletions and mutational experiments indicate that (i) a cAMP-response element-like sequence (CLS) present at -208 to -200 bp is the main element… CONTINUE READING
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