The absence of a clathrin adapter confers unique polarity essential to proximal tubule function.

@article{Schreiner2010TheAO,
  title={The absence of a clathrin adapter confers unique polarity essential to proximal tubule function.},
  author={Ryan Schreiner and Gustavo Frindt and Fernando L{\'o}pez D{\'i}az and Jose Maria Carvajal-Gonzalez and Andres E. Perez Bay and Lawrence G. Palmer and Vladimir Marshansky and Dennis L. Brown and Nancy J. Philp and Enrique Rodr{\'i}guez-Boulan},
  journal={Kidney international},
  year={2010},
  volume={78 4},
  pages={382-8}
}
It is well established that many cognate basolateral plasma membrane proteins are expressed apically in proximal tubule cells thus optimizing the reabsorption capacity of the kidney. The protein clathrin and its adapter proteins normally regulate basolateral polarity. Here we tested whether the unique proximal tubule polarity is dependent on an epithelial-specific basolateral clathrin adapter, AP1B, present in most other epithelia. Quantitative PCR of isolated mouse renal tubules showed that… CONTINUE READING

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Quantitative PCR of isolated mouse renal tubules showed that AP1B was absent in proximal tubules but present in medullary and cortical thick ascending limbs of Henle , and cortical collecting ducts .
Quantitative PCR of isolated mouse renal tubules showed that AP1B was absent in proximal tubules but present in medullary and cortical thick ascending limbs of Henle , and cortical collecting ducts .
Quantitative PCR of isolated mouse renal tubules showed that AP1B was absent in proximal tubules but present in medullary and cortical thick ascending limbs of Henle , and cortical collecting ducts .
Quantitative PCR of isolated mouse renal tubules showed that AP1B was absent in proximal tubules but present in medullary and cortical thick ascending limbs of Henle , and cortical collecting ducts .
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