The absence of Prep1 causes p53-dependent apoptosis of mouse pluripotent epiblast cells.

Abstract

Disruption of mouse Prep1, which codes for a homeodomain transcription factor, leads to embryonic lethality during post-implantation stages. Prep1(-/-) embryos stop developing after implantation and before anterior visceral endoderm (AVE) formation. In Prep1(-/-) embryos at E6.5 (onset of gastrulation), the AVE is absent and the proliferating extra… (More)
DOI: 10.1242/dev.050567

Cite this paper

@article{FernandezDaz2010TheAO, title={The absence of Prep1 causes p53-dependent apoptosis of mouse pluripotent epiblast cells.}, author={Luis C Fernandez-D{\'i}az and Audrey Laurent and Sara Girasoli and Margherita Yayoi Turco and Elena Longobardi and Giorgio Antonio Iotti and Nancy A. Jenkins and Maria Teresa Fiorenza and Neal G. Copeland and Francesco Blasi}, journal={Development}, year={2010}, volume={137 20}, pages={3393-403} }