The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer.

@article{Lin2009TheAO,
  title={The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer.},
  author={Songbai Lin and Dongsheng Wang and Smita S Iyer and Amr M. Ghaleb and Hyunsuk Shim and Vincent W. Yang and Jerold Chun and C H Chris Yun},
  journal={Gastroenterology},
  year={2009},
  volume={136 5},
  pages={1711-20}
}
BACKGROUND & AIMS Chronic inflammation is a risk factor for colon cancer (CC). Lysophosphatidic acid (LPA), a naturally produced phospholipid, mediates multiple effects that are vital to disease process, including inflammation and cancer. The expression of LPA receptor 2 (LPA2) is up-regulated in several types of cancer, including ovarian and colon cancer, but the importance of LPA and LPA2 in the development and progression of CC is unclear. In this study, we sought to determine whether LPA… CONTINUE READING

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