The absence of GH signaling affects the susceptibility to high-fat diet-induced hypothalamic inflammation in male mice.

@article{Baquedano2014TheAO,
  title={The absence of GH signaling affects the susceptibility to high-fat diet-induced hypothalamic inflammation in male mice.},
  author={Eva Baquedano and Ana M. Ruiz-Lopez and Elahu Gosney Sustarsic and James Herpy and Edward O. List and Julie A Chowen and Laura M Frago and John J. Kopchick and Jes{\'u}s Argente},
  journal={Endocrinology},
  year={2014},
  volume={155 12},
  pages={4856-67}
}
GH is important in metabolic control, and mice with disruption of the gene encoding the GH receptor (GHR) and GH binding protein (GHR-/- mice) are dwarf with low serum IGF-1 and insulin levels, high GH levels, and increased longevity, despite their obesity and altered lipid and metabolic profiles. Secondary complications of high-fat diet (HFD)-induced obesity are reported to be associated with hypothalamic inflammation and gliosis. Because GH and IGF-1 can modulate inflammatory processes, our… CONTINUE READING
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